Switching TDF/FTC/EFV to TDF/FTC/RPV VS Continuing TDF/FTC/EFV in HIV Patients With Complete Virological Suppression
Status:
Completed
Trial end date:
2018-04-30
Target enrollment:
Participant gender:
Summary
According to the Thai National Guidelines for Treatment of HIV/AIDS 2014, the recommended
first line ART regimen was 2 NRTIs backbone, TDF and FTC; plus 1 NNRTI, EFV, with RPV as an
alternative one. Most of the randomized-controlled studies, including ECHO and THRIVE, showed
the non-inferiority of RPV compared with EFV in naive cases. But there were not much
randomized-controlled trials for changing from other NRTI to RPV in patients who currently on
another ART, especially in Thailand. Moreover, the concerned adverse effects of dyslipidemia
and neurological symptoms were better in RPV-based than EFV-based regimen. Finally, the
cost-effectiveness and universal coverage are also the benefit of RPV over EFV in term of
economics.