Overview

Surgical Site Infections After Liver Transplantation Based on Perioperative Antibiotics

Status:
Completed
Trial end date:
2015-10-01
Target enrollment:
0
Participant gender:
All
Summary
This study will be to prospectively determine differences in Surgical Site Infection (SSI) if a prolonged course of post-operative antibiotics are used following liver transplantation.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
National Institute of General Medical Sciences (NIGMS)
University of Virginia
Collaborator:
National Institute of Allergy and Infectious Diseases (NIAID)
Treatments:
Anti-Bacterial Agents
Antibiotics, Antitubercular
Liver Extracts
Piperacillin, tazobactam drug combination
Criteria
Inclusion Criteria:

- All patients ≥ 18 years of age.

- Eligible for liver transplantation by UVA standard protocol.

- First-time transplantation.

- No active infections - requiring antibiotics - excluding antifungals.

Exclusion Criteria:

- All patients < 18 years of age.

- Previous liver transplantation.

- Active infections - requiring antibiotics.

- Allergy to all standard peri-operative antibiotics (piperacillin/tazobactam or UVA
standard alternatives for Penicillin allergic patients: ciprofloxacin and vancomycin).