Surgery and Heated Chemotherapy for Adrenocortical Carcinoma
Status:
Completed
Trial end date:
2018-08-09
Target enrollment:
Participant gender:
Summary
Background:
- Adrenocortical carcinoma (ACC) is a rare tumor of the adrenal gland. Few people who develop
this disease live more than 5 years after being diagnosed. Those whose tumors have spread
inside their abdomen may have an especially poor outcome. In these cases, traditional
chemotherapy is not very effective. One possible new treatment is aggressive surgery with
heated chemotherapy. This type of treatment has been more effective for other types of cancer
in the abdomen. Researchers want to see this if approach can improve the outcomes of people
with ACC.
Objectives:
- To test the safety and effectiveness of surgery and heated chemotherapy for ACC.
Eligibility:
- Individuals at least 18 years of age who have advanced ACC.
Design:
- Participants will be screened with a physical exam and medical history. Blood samples
will be collected. Heart function tests will be given. Imaging studies will be used to
locate the surgical sites before the operation.
- Participants will have surgery to remove ACC tumor tissue. After the tumors have been
removed, they will have heated chemotherapy with cisplatin. The heat may help weaken any
remaining cancer cells and make them easier to destroy. It will also focus the treatment
on the tumor sites, rather than the whole body.
- Participants will recover in the hospital for several days after surgery. They will have
regular follow-up visits to monitor the outcome of the surgery.