Surfactant Application During Spontaneous Breathing With Continuous Positive Airway Pressure (CPAP) in Premature Infants < 27 Weeks

• Status: Completed
• Trial end date: 2012-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This study investigates the efficacy of surfactant application during spontaneous breathing with CPAP in avoiding death and chronic lung disease (CLD) in very immature infants with a gestational age of less than 27 weeks.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Cologne
• Collaborators: Altona Children's Hospital; Asklepios Kliniken Hamburg GmbH; Charite University, Berlin, Germany; DRK Kinderklinik Siegen; German Federal Ministry of Education and Research; Heinrich-Heine University, Duesseldorf; Hospital of Leverkusen; Kliniken der Stadt Koeln, Kinderkrankenhaus Riehl; Klinikum Aschaffenburg-Alzenau; Klinikum Stuttgart; Ruhr University of Bochum; The Clinical Trials Centre Cologne; University Hospital Schleswig-Holstein; University Hospital, Bonn; University of Schleswig-Holstein; Vestische Kinder- und Jugendklinik Datteln
• Treatments: Poractant alfa; Pulmonary Surfactants

Criteria

Inclusion Criteria:

• IRDS with Silverman-Score ≥ 5 and / or FiO2 ≥ 0,3

• Postnatal age of more than 10 min. and less than 2 hours

• Gestational age ≥ 23+0 and < 27+0

Exclusion Criteria:

• Primary cardio- pulmonary resuscitation

• Prenatally diagnosed severe malformation

• No parental consent

• Participation in another interventional trial