Stroke is the second leading cause of death worldwide. One of the causes of stroke which can
be treated is narrowing of the carotid artery. Currently the only definite treatment option
is surgery or endovascular treatment. All patients not qualified for or awaiting surgery are,
therefore, left with best medical therapy and with a yearly risk of stroke anywhere between
1% - 35% depending on the severity of the disease.
The study will use the properties of a tomato extract containing lycopene. Previously studies
have demonstrated beneficial properties of tomato extracts:
1. It decreases lipid oxidation
2. It decreases DNA damage
3. It has properties that reduce the speed and amount of cell divisions that inflammatory
and smooth muscle cells undergo (both of these cell types contribute to atheroma
formation).
The investigators wish to assess whether long-term food supplementation with a tomato extract
containing lycopene could influence atherosclerotic plaque characteristics. The investigators
will assess this using Magnetic Resonance Imaging of the plaque and transcranial Doppler
ultrasonography for counting the number of blood clots that go to the brain's arteries.
Furthermore the investigators wish to examine the effect of long-term food supplementation
with a tomato extract containing lycopene on blood cholesterol levels and lipid oxidation and
blood markers of inflammation and injury of the inner lining of the arteries.
This will be a single center, double blind, randomised, placebo controlled study.
Phase:
N/A
Details
Lead Sponsor:
Cambridge University Hospitals NHS Foundation Trust