Supplementation of Glutamine and Fish Oil Versus Placebo in Patients With Heart Failure
Status:
Completed
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
The aim of this study is to determine whether supplementation of glutamine and fish oil can
improve peripheral skeletal muscle function and metabolism in patients with heart failure.
The investigators propose a randomized, double-blind, placebo controlled study comparing the
combined supplementation of fish oil and glutamine with placebo in patients with stable heart
failure. 30 patients with heart failure will be randomized to either receiving 6.5 g fish
oil/d and 8 g glutamine/d (n=15) or placebo (n=15) for 90 days. The primary outcome in this
study is the change in muscle functional capacity measured as changes in maximum muscle
strength and fatigability, peak VO2 and exercise time after supplementation. A secondary
outcome is the measurement of systemic and local markers of inflammation.