Sulfadoxine- Pyrimethamine Versus Weekly Chloroquine for Malaria Prevention in Children With Sickle Cell Anemia
Status:
Completed
Trial end date:
2007-02-01
Target enrollment:
Participant gender:
Summary
Malaria is fatal and increases the risk of death among children with sickle cell anemia.
Chemoprophylaxis significantly improves quality of life in these children. In Uganda
Chloroquine is the drug of choice for prophylaxis and yet it's effectiveness is limited due
to high levels of resistance throughout the country. Intermittent presumptive treatment with
sulfadoxine - Pyrimethamine a new approach to malaria prevention, has shown great potential
in reducing incidence of malaria and anaemia among high risk groups such as pregnant women
and infants. However no studies have been done in Uganda to determine if presumptive
treatment with sulfadoxine- pyrimethamine reduces the incidence of malaria in children with
sickle cell anaemia.
Hypothesis : Presumptive treatment with sulfadoxine- Pyrimethamine is better than weekly
chloroquine in reducing incidence of malaria in children with sickle cell anaemia.
Phase:
Phase 3
Details
Lead Sponsor:
Makerere University
Treatments:
Chloroquine Chloroquine diphosphate Fanasil, pyrimethamine drug combination Pyrimethamine Sulfadoxine