Suitability of a Low Dose Lipopolysaccharide (LPS) Inhalation as a Challenge Model
Status:
Completed
Trial end date:
2012-01-01
Target enrollment:
Participant gender:
Summary
This pilot study is planned to assess the suitability of a low dose Lipopolysaccharide (LPS)
inhalation as a challenge model. As LPS effects are based on a different mode of action, this
challenge model will provide the possibility to test a wider spectrum of potential drugs in
the future. Provided that the LPS response is reproducible, it is planned to test whether a
single high dose of inhaled steroid can serve as a positive control in the LPS model. Another
major aim of the study is to test a variety of novel tools for the non-invasive assessment of
airway inflammation induced by LPS challenge.
Phase:
N/A
Details
Lead Sponsor:
Fraunhofer-Institute of Toxicology and Experimental Medicine