Sublingual Misoprostol & Isoflurane During Caesarean Section

• Status: Completed
• Trial end date: 2011-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

Misoprostol would reduce the uterine bleeding after caesarean delivery, without harmful effects on either mother or baby. The investigators postulated that the use of sublingual misoprostol during isoflurane anaesthesia for uncomplicated caesarean delivery would reduce maternal haemorrhage, uterine atonic effects, and the need for additional uterotonic agents, without harmful effects on either mother or baby. Therefore, the present study was designed to evaluate the effects of preoperative sublingual misoprostol on maternal blood loss, uterine tone, the need for additional oxytocin and neonatal outcome after elective caesarean delivery under isoflurane anaesthesia.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mansoura University
• Treatments: Isoflurane; Misoprostol

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists class I and II

• parturients aged 18-35 years

• uncomplicated singleton pregnancies

• Gestational age >= 36 weeks

• elective caesarean delivery

• refused regional anaesthesia

• requested general anaesthesia.

Exclusion Criteria:

• allergy to prostaglandins

• bronchial asthma

• anaemia

• bleeding disorders

• cardiac diseases

• inflammatory bowel diseases

• multiple pregnancies

• preeclampsia

• placenta praevia

• abruptio placenta

• previous postpartum haemorrhage

• antepartum haemorrhage

• grand multiparity

• uterine fibroids

• intrauterine growth restriction

• fetal abnormality