For people who identify as transgender, there is a strong sense that they were born into the
wrong body and that their outward looking body does not match how they truly feel about
themselves. They feel male, not female and have always felt that way. There is a great deal
of discomfort or dysphoria about looking and feeling female, and there is a strong desire to
achieve a more masculine appearance. While surgery, clothing and hair for example, can help a
person appear more like a male, many transgender males will want to take testosterone to make
them feel and look more masculine.
This usually involves injecting testosterone into a muscle every 1-2 weeks for many years.
Intramuscular injections can often be uncomfortable or painful, and requires the patient to
be taught how to inject themselves. Or somebody else has to do it. There is a growing trend
in some transgender men to give their injection just below the skin or subcutaneously (like
insulin in a diabetic), because it is less uncomfortable but we don't really know if
testosterone gets into the blood in the same way. At least one clinic in the US already
suggests that patients can use the subcutaneous method but there is almost no research to
show it's the same as intramuscular.
Our project will be looking at a small group of transgender males who are already on
intramuscular testosterone and then switch them over to the same dose of subcutaneous
testosterone, and then compare their levels of testosterone. If those levels are similar,
then patients may chose the less uncomfortable subcutaneous injection.