Subcutaneous Progesterone Versus Vaginal Progesterone Gel for Luteal Phase Support
Status:
Completed
Trial end date:
2016-05-01
Target enrollment:
Participant gender:
Summary
It is well known that implantation of the developing blastocyst occurs during the luteal
phase of the menstrual cycle when the endometrium is under the direct influence of
Progesterone (P).Several prospective randomized controlled trials have evaluated the benefits
of luteal phase P support in ovulation induction cycles and a recent review and meta-analysis
demonstrated that it may be of benefit to patients undergoing ovulation induction with
gonadotropins in intrauterine insemination (IUI) cycles. Until now, injectable P was offered
only in an oil-base solution owing to the insoluble properties of the molecule, which made
the IM route mandatory. A recent publication, however, demonstrated the efficacy of a new P
formulation that could be a game changer. The aim of the present pilot trial will be to
compare the efficacy and tolerability of 25 mg/d of the new SC P with 90 mg/d of vaginal gel
P for luteal phase support (LPS) in COH and IUI cycles.