Subarachnoidal Anesthesia: Dexmedetomidine vs Fentanyl Plus Hyperbaric Bupivacaine for Lower Abdomen Surgery

• Status: Completed
• Trial end date: 2015-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Dexmedetomidine, highly selective agonist for alpha-2 receptors, enhances the sensory and motor block with prolonged postoperative analgesia without hemodynamic compromise.

OBJECTIVE: To evaluate effects of dexmedetomidine vs fentanyl with hyperbaric bupivacaine spinal anesthesia for lower abdominal surgeries.

METHODS: double-blind, randomized, American Society Anesthesiologist classification (ASA) : I

• II, 18-65 years. F group (23 patients) received 25 mcg fentanyl, Group D (27 patients), 10 mcg dexmedetomidine with 12.5 mg hyperbaric bupivacaine . 0,02mgrs morphine / kg intravenously if EVA≥4was administered in postoperative period. Hemodynamic variables and O2 saturation intraoperatively was recorded, EVA every 4 hours, side effects, sensory block, motor, sedation and peripheral neurological manifestations of toxicity.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital Central Dr. Luis Ortega
• Treatments: Anesthetics; Bupivacaine; Dexmedetomidine; Fentanyl

Criteria

Inclusion Criteria:

• ASA I and II

• lower abdominal surgery

Exclusion Criteria:

• Consumption antagonists adrenergic or channel blockers Ca ++

• Patients with arrhythmias or heart block

• Allergic to any drugs under study

• Obese

• Physical or mental incapacity to understand and use the pain scale

• Contraindication for anesthesia conductive

• Realization difficulty or complication during anesthesia and / or surgery