Studying the Role of Brain Molecules for Decision Making
Status:
Recruiting
Trial end date:
2023-05-31
Target enrollment:
Participant gender:
Summary
The aim of the present project is to elucidate the neuropharmacological mechanisms underlying
value (choice preference) and attention (choice randomness) processing in humans. More
specifically, the investigators test whether dopaminergic, noradrenergic and cholinergic
interventions affect neural and behavioral processing of valuation and attention during
decision-making. The investigators do this by up-regulating dopaminergic, noradrenergic or
cholinergic neurotransmission pharmacologically through administration of methylphenidate,
reboxetine, or nicotine. We test the hypothesis that methylphenidate, reboxetine, or nicotine
reduce choice randomness and that this effect is underpinned by an effect on attention and/or
value processing.