Studying the Effect of Changing Immunosuppression in Case of Polyoma BK Virus Infection of the Renal Transplant
Status:
Unknown status
Trial end date:
2018-10-01
Target enrollment:
Participant gender:
Summary
Polyomavirus BK nephropathy is a serious complication after renal transplantation leading to
graft loss in 40% of cases. Since no virustatic drug exists, the investigators want to study
the best way to manage viral invasion by changing the immunosuppressive treatment comparing
two treatment schemes. The investigators hypothesis is that switching to an mTOR-based scheme
is superior to a general decrease of a calcineurin inhibitor (CNI)-based scheme. The study
will be performed as a prospective, randomized, parallel group comparison.