Study to Investigate the Analgesic Efficacy of a Single Dose of AZD1386

• Status: Completed
• Trial end date: 2008-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary aim of this study is to investigate if AZD1386 can relieve the pain induced by the surgical removal of one lower wisdom-tooth. This will be done by comparing the effect of AZD1386 to placebo ("inactive substance") on pain. A number of patients will instead receive the common painkiller naproxen for comparison purposes. Rescue medication, acetaminophen, will be allowed if a need for additional painkillers would arise. A number of patients will receive naproxen as control.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: AstraZeneca
• Treatments: Analgesics; Naproxen

Criteria

Inclusion Criteria:

• Patients scheduled for surgical removal of one partial or complete impacted mandibular third molar.

• Provision of signed informed consent.

Exclusion Criteria:

• History of somatic disease/condition, which may interfere with the objectives for the study, as judged by the investigator.

• Clinically significant illness or clinically relevant trauma within the 2 weeks prior to the administration of the investigational product, as judged by the investigator.

• A family history of short QT syndrome (SQTS) or sudden cardiac death (SCD) amongst first degree relatives

• Patients with a body temperature >37.5°C at Visit 2, before start of surgical procedures