Study to Investigate Effects of Antiischemic Drug Therapy in Silent Ischemia
Status:
Completed
Trial end date:
2006-04-01
Target enrollment:
Participant gender:
Summary
There is a lack of data on the prognostic importance of silent ischemia in totally
asymptomatic subjects without history of coronary artery disease (CAD), and, particularly, on
a possible benefit of medical therapy in such patients. SWISSI 1 therefore recruits totally
asymptomatic subjects older than 40 years of age without any history of CAD but one
cardiovascular risk factor with documented silent ischemia. Participants are randomized to
open antianginal drug therapy and risk factor control versus only risk factor management and
followed up for ≥ 10 years.