Study to Improve Scientific Understanding of the Cardiovascular Actions of Cocaine

• Status: Withdrawn
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to improve the scientific understanding of the cardiovascular actions of cocaine, in particular the ability of cocaine to increase blood pressure.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Texas Southwestern Medical Center
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Cocaine; Dexmedetomidine

Criteria

Inclusion Criteria:

• Cocaine naive healthy volunteers

Exclusion Criteria:

• Any evidence of cardiopulmonary disease by history or physical examination

• History of hypertension or 24 hour blood pressure averaging >135/85 mmHg

• Any history of substance abuse (other than tobacco)

• Diabetes mellitus or other systemic illness

• Individuals with a history of pseudocholinesterase deficiency

• Pregnancy