Overview

Study to Evaluate the Safety and Efficacy of Magrolimab in Combination With Nab-Paclitaxel or Paclitaxel Versus Nab-Paclitaxel or Paclitaxel in Previously Untreated Adults With Metastatic Triple-Negative Breast Cancer

Status:
Recruiting
Trial end date:
2023-11-01
Target enrollment:
0
Participant gender:
All
Summary
The primary objective of this study for the Safety Run-In Cohort is to evaluate the safety, tolerability, and recommended Phase 2 dose (RP2D) of magrolimab in combination with nab-paclitaxel or paclitaxel in metastatic triple-negative breast cancer (mTNBC). The primary objective of this study for the Randomized Cohorts is to evaluate the efficacy of magrolimab in combination with nab-paclitaxel or paclitaxel in solid tumors as determined by progression-free survival (PFS) by investigator assessment.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Gilead Sciences
Treatments:
Albumin-Bound Paclitaxel
Magrolimab
Paclitaxel
Criteria
Key Inclusion Criteria:

- Individual has provided informed consent

- Individual is willing and able to comply with clinic visits and procedures outlined in
the study protocol

- Individuals must have an Eastern Cooperative Oncology Group (ECOG) performance status
of 0 or 1

- Laboratory measurements, blood counts: Adequate hemoglobin, neutrophil, and platelet
counts

- Laboratory measurements, renal function: Adequate creatinine and liver function tests

- Male and female individuals of childbearing potential who engage in heterosexual
intercourse must agree to use protocol-specified method(s) of contraception

- Measurable disease according to RECIST, version 1.1. Previously irradiated lesions can
be considered as measurable disease only if disease progression has been unequivocally
documented at that site since radiation

- Individuals must be willing to provide baseline tumor tissue from a core or excisional
biopsy (fine needle aspirate is not adequate). A newly obtained biopsy (within 90 days
prior to study treatment start) is strongly preferred, but an archival sample (within
6 months prior to study treatment start) is acceptable. Individuals will also be
requested to consent to a mandatory on-treatment tumor biopsy unless not feasible as
determined by the investigator and discussed with the sponsor

- Individuals previously untreated for unresectable locally advanced or mTNBC that is
histologically or cytologically confirmed based on the most recent analyzed biopsy or
other pathology specimen, as defined by the most recent American Society of Clinical
Oncology/College of American Pathologists (ASCO/CAP) guideline

- Individuals whose tumors do not express programmed cell death ligand 1 (PD-L1), as
determined by an approved test according to local regulations

- Prior systemic treatment for neoadjuvant and/or adjuvant therapy and/or curative
intent radiation therapy is permitted if completed at least 6 months prior to
enrollment.

Note: Maintenance therapies are not counted as separate lines of therapy.

Key Exclusion Criteria:

- Positive serum pregnancy test

- Breastfeeding female

- Active central nervous system (CNS) disease. Individuals with asymptomatic and stable,
treated CNS lesions (radiation and/or surgery and/or other CNS-directed therapy who
have not received corticosteroids for at least 4 weeks) are allowed

- Red blood cell (RBC) transfusion dependence, defined as requiring more than 2 units of
packed RBC transfusions during the 4-week period prior to screening. RBC transfusions
are permitted during the screening period and prior to enrollment to meet the
hemoglobin inclusion criteria

- History of hemolytic anemia, autoimmune thrombocytopenia, or Evans syndrome in the
last 3 months

- Known hypersensitivity to any of the study drugs, the metabolites, or formulation
excipient

- Prior treatment with cluster of differentiation 47 (CD47) or signal regulatory protein
alpha-targeting agents

- Current participation in another interventional clinical trial

- Known inherited or acquired bleeding disorders

- Significant disease or medical conditions, as assessed by the investigator and
sponsor, that would substantially increase the risk-benefit ratio of participating in
the study

- Known active or chronic hepatitis B or C infection or human immunodeficiency virus
infection in medical history)

- Prior anticancer therapy including but not limited to chemotherapy, immunotherapy, or
investigational agents within 4 weeks prior to magrolimab is not permitted.

Note: Other protocol defined Inclusion/Exclusion criteria may apply.