Overview
Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MK-1029 in Participants With Mild to Moderate Asthma
Status:
Completed
Completed
Trial end date:
2011-12-27
2011-12-27
Target enrollment:
0
0
Participant gender:
All
All
Summary
This study will evaluate the safety, tolerability, and pharmacokinetics (PK) of multiple dose treatment with MK-1029 in adults with mild to moderate persistent asthma.Phase:
Phase 1Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Merck Sharp & Dohme Corp.
Criteria
Inclusion Criteria:- If female, must be of non-childbearing potential
- Have a history of mild to moderate asthma for at least 6 months
- Other than asthma, in general good health
- Able to perform reproducible pulmonary function testing
- Is a nonsmoker and/or has not used nicotine or nicotine-containing products for at
least 12 months
- Have body mass index (BMI) ≥17 kg/m^2, but ≤35 kg/m^2
Exclusion Criteria:
- Demonstrate a decrease in absolute forced expiratory volume in 1 second (FEV1) of >20%
from the Screening Visit to the Baseline Visit
- Experience a decrease in AM or PM peak expiratory flow (PEF) below the Stability Limit
on any 2 consecutive days prior to the Baseline Visit
- Require the use of >8 inhalations per day of short-acting beta2-agonist metered dose
inhaler (MDI) or >2 nebulized treatments per day of 2.5 mg albuterol, on any 2
consecutive days from the Screening Visit up to the Baseline Visit
- Experience an exacerbation defined as a clinical deterioration of asthma, as judged by
the clinical investigator, that results in emergency treatment, hospitalization due to
asthma, or treatment with additional, excluded medication (other than short-acting
beta agonists [SABA]) at any time from the Screening Visit up to the Baseline Visit
- Have been hospitalized for treatment of asthma or required oral corticosteroids for
treatment of asthma within the past 6 months, or has ever required ventilator support
for respiratory failure secondary to asthma
- Require the chronic use of high-dose inhaled corticosteroids
- Have been diagnosed with chronic obstructive pulmonary disease (COPD) or any other
clinically relevant lung disease, other than asthma
- Have a history of any illness that might confound the results of the study or poses
additional risk to the participant
- Have had recent (within 4 weeks of first dose) or ongoing upper or lower respiratory
tract infection
- Is nursing
- Have a history of significant multiple and/or severe allergies (including latex
allergy), or has had an anaphylactic reaction or significant intolerability to
prescription or non-prescription drugs or food