Study to Evaluate the Effectiveness of High Dose Statin Loading in Acute Heart Failure Patients

• Status: Completed
• Trial end date: 2013-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a prospective, single-center, randomized, controlled, open-label, pilot study to evaluate the effectiveness of high dose statin loading in acute heart failure patients.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Yonsei University
• Treatments: Hydroxymethylglutaryl-CoA Reductase Inhibitors

Criteria

Inclusion Criteria:

• Dyspnea at rest or minimal activity

• Tachypnea (respiratory rate > 20/min) or rales or pulmonary edema on chest X-ray

Exclusion Criteria:

• Acute coronary Syndrome

• Hospitalization plan for PTCA or CABG

• Cardiogenic shock (Systolic Blood Pressure < 80mmHg)

• Uncontrolled hypertension (Systolic Blood Pressure > 180mmHg)

• Allergy, adverse drug reaction, hypersensitivity to statin

• Troponin > 5 times upper limit of normal (ULN)

• Creatinine kinase-MB level > 3 times ULN

• AST, ALT > 3 times ULN or acute hepatitis

• Current or past history of muscle disease, rhabdomyolysis

• Life expectancy < 6 months (e.g. metastatic malignancy, liver cirrhosis)

• Pregnancy or women at age of childbearing potential