Study to Evaluate the Effect of Simvastatin, Losartan and Pioglitazone on Patients With Peripheral Arterial Disease.
Status:
Completed
Trial end date:
2007-08-01
Target enrollment:
Participant gender:
Summary
Part A. The purpose of this study is to assess the effects of 6 weeks of treatment with,
simvastatin, losartan or pioglitazone compared to placebo on the RNA expression profile of
lower extremity peripheral arterial atherosclerotic plaque. Part B. The effect of
simvastatin, losartan or pioglitazone compared to placebo on protein and lipid biomarkers in
lower extremity peripheral arterial atherosclerotic plaque.