Overview

Study to Evaluate the Effect of IW-3718 on the Pharmacokinetics of Oral Contraceptive, Levothyroxine, Glyburide, and Digoxin in Healthy Adult Volunteers

Status:
Completed

Trial end date:
2019-07-03

Target enrollment:

Participant gender:

Summary

The primary objectives of this study are the following: - To evaluate the pharmacokinetics (PK) of a monophasic oral contraceptive's active components, ethinyl estradiol (EE) and norethindrone acetate (NET), following a single oral dose alone and in combination with IW-3718 in healthy adult female participants. - To evaluate the PK of levothyroxine following a single oral dose alone and in combination with IW-3718 in healthy adult participants. - To evaluate the PK of glyburide following a single oral dose alone and in combination with IW-3718 in healthy adult participants. - To evaluate the PK of digoxin following a single oral dose alone and in combination with IW-3718 in healthy adult participants.

Phase:

Phase 1

Details

Lead Sponsor:

Ironwood Pharmaceuticals, Inc.

Treatments:

Contraceptive Agents
Contraceptives, Oral
Digoxin
Estradiol
Ethinyl Estradiol
Glyburide
Norethindrone