Study to Evaluate Hemodynamic Response to to a Sublingual Dose of Glyceryl Trinitrate in Subjects Receiving TA-1790, Sildenafil Citrate, and Placebo

• Status: Completed
• Trial end date: 2004-05-01
• Target enrollment: 0
• Participant gender: Male

Summary

The objective of this study is to evaluate the hemodynamic response to a sublingual dose of glyceryl trinitrate in subjects receiving oral TA-1790, sildenafil citrate, and placebo.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: VIVUS, Inc.
• Treatments: Citric Acid; Nitroglycerin; Sildenafil Citrate

Criteria

Inclusion Criteria:

• Provide written informed consent

• Willing to comply with all study requirements and clinic schedules

• Male between 30 to 60 years of age

• Non-smoker

• No history of alcohol abuse

• Normal screening laboratory values

Exclusion Criteria:

• Allergy or hypersensitive to PDE5 inhibitors

• Evidence of clinically significant disease

• Supine systolic/diastolic blood pressure level

• History of cardiovascular disease

• Previously participated in TA-1790 within the past 30 days