Overview
Study to Evaluate Botulinum Neurotoxin Serotype E (EB-001) in Reducing Musculoskeletal Pain in Abdominoplasty
Status:
Terminated
Terminated
Trial end date:
2018-07-10
2018-07-10
Target enrollment:
0
0
Participant gender:
All
All
Summary
To determine the safety and efficacy of single intra-operative treatment of Botulinum Neurotoxin Serotype E (EB-001) intramuscular (IM) injections into the Rectus Abdominus (RA) in participants undergoing abdominoplasty.Phase:
Phase 2Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Allergan
Bonti, Inc.Treatments:
Botulinum Toxins
Criteria
Inclusion Criteria:1. Men or women 23 to 55 years of age, inclusive
2. Scheduled to undergo elective abdominoplasty surgery with full length plication from
xyphoid to pubis, and removal of skin/fat flap under general anesthesia (endotracheal
or otherwise) without liposuction
3. American Society of Anesthesiologist (ASA) Physical Class 1-2.
Exclusion Criteria:
1. History of prior major abdominal surgery as judged by the investigator
2. Pre-existing lung disease that could impact participant safety in the opinion of the
investigator
3. Pre-existing disorders of the neuromuscular junction (myasthenia gravis, Eaton-
Lambert syndrome, or amyotrophic lateral Sclerosis)
4. At high risk of deep vein thrombosis as judged by the investigators determined by a
Caprini score of 3 or higher
5. Slow vital capacity that is below 80% of normal value for respective race, age,
height, and gender or below 2.5 Liters (L) of absolute volume
6. Pulse oximetry below 95%
7. Body weight less than 50 kg (110 pounds) or a Body Mass Index (BMI) of ≥ 32
8. Reported use of any botulinum toxin within 3 months prior to the date of surgery
9. Use of long acting opioids within 3 days or any opioid medication within 24 hours
prior to surgery
10. Aminoglycoside intake within 48 hours prior to or during surgery
11. Participants on anti-depressant or anti-psychotic medications
12. Reported pain score of 2 or more at screening on the 11-point scale numerical pain
rating scale-administered after an activity (NPRS-A) following an activity after and
walking approximately 10 feet.