Overview
Study to Determine the Safety and Efficacy of Ribociclib in Combination With Hormone Therapy and Hypofractionated Radiotherapy in Breast Cancer, With Positive Hormone Receptors and Negative HER2 Status, in Newly Diagnosed, Not Immediately Operable E
Status:
Not yet recruiting
Not yet recruiting
Trial end date:
2032-03-01
2032-03-01
Target enrollment:
0
0
Participant gender:
Female
Female
Summary
Women aged 70 years or older, newly diagnosed for locally advanced unilateral breast cancer, with a histological diagnosis of invasive mammary carcinoma, positive hormone receptors, HER2 status Negative, not immediately operable (stage of disease, comorbidities or refusal of surgery) with tumor in place, with indication of treatment with hormone therapy and hypofractionated radiotherapy, not eligible for neoadjuvant chemotherapy and without major comorbidity contraindicating the proposed treatment regimen.Phase:
Phase 1/Phase 2Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Centre Antoine Lacassagne
Criteria
Criteria for registration phase Inclusion criteria1. Written informed consent must be obtained prior to any screening procedures;
2. Women ≥ 70 years old at the time of signing informed consent;
3. Have a performance status of 0 to 2 on the ECOG Performance Scale ;
4. Newly diagnosed for non-metastatic unilateral breast cancer;
5. Histological diagnosis of invasive mammary carcinoma, positive hormone receptors, HER2
status Negative defined as a negative in situ hybridization test or an IHC status of
0, 1+ or 2+. If IHC is 2+, a negative in situ hybridization (FISH, CISH, or SISH) test
is required by local laboratory testing and based on the most recently analyzed tissue
sample;
6. Not immediately operable (stage of disease, comorbidities or refusal of surgery) with
tumor in place;
7. Measurable disease based on RECIST 1.1 (a lesion at a previously irradiated site may
only be counted as a target lesion if there is a clear sign of progression since the
irradiation).
8. Demonstrate adequate organ functions:
1. Hemoglobin > 9 g/dL;
2. Absolute neutrophil count > 1.5 G/L;
3. Platelets > 100 G/L;
4. INR ≤1.5 (unless the patient is receiving anticoagulants and the INR is within
the therapeutic range of intended use for that anticoagulant within 7 days prior
to the first dose of study drug);
5. Total serum bilirubin < ULN; or total bilirubin ≤ 3.0 × ULN or direct bilirubin ≤
1.5 × ULN in patients with well documented Gilbert's Syndrome
6. AST and ALT < 2.5 x ULN;
7. Alkaline Phosphatase < 2.5 x ULN
8. Calculated creatinine clearance > 30 ml/min using MDRD formula;
9. Patient must have the following laboratory values within normal limits or
corrected to within normal limits with supplements (the local laboratory value
should be documented within normal limits after the correction) before
registration:
- Potassium
- Magnesium
- Total Calcium (corrected for serum albumin);
9. Standard 12-lead ECG values defined as the mean of the triplicate ECGs
- QTcF interval at screening < 450 msec (QT interval using Fridericia's correction)
- Mean resting heart rate 50-90 bpm (determined from the ECG)
10. Indication of treatment with hormone therapy and hypofractioned radiotherapy;
11. Patients having taken cognizance of the information sheet and having signed the
informed consent;
12. Patients covered by medical insurance.
13. Must be able to swallow ribociclib;
14. Subjects must be able to communicate with the investigator and comply with the
requirements of the study procedures;
15. Must be willing to remain at the clinical site as required by the protocol.
Exclusion criteria
1. Patient eligible to resection surgery and agreed to proceed with the surgery;
2. Patient eligible to neoadjuvant chemotherapy;
3. Patient with distant metastases of breast cancer beyond regional lymph nodes (stage IV
according to AJCC 8th edition);
4. Concomitant bilateral breast cancer;
5. Previous treatment, in the 2 years before inclusion, by chemotherapy, hormone therapy,
thoracic surgery or radiotherapy for a malignant tumor;
6. Tumor in previously irradiated territory;
7. Patient has received any CDK4/6 inhibitor;
8. Patient with a known hypersensitivity to any of the excipients of Ribociclib and/or
hormono therapy (e.g. rare hereditary problems of galactose intolerance, the Lapp
lactase deficiency, glucose-galactose malabsorption, and soy allergy);
9. Known additional malignancy. Exceptions include basal cell carcinoma of the skin or in
situ cervical cancer that has undergone potentially curative therapy;
10. Contraindication for hormone therapy , Ribociclib or radiotherapy;
11. Severe dementia;
12. Patient has had major surgery within 14 days prior to starting study drug or has not
recovered from major side effects.
13. Patient has any other concurrent severe and/or uncontrolled medical condition that
would, in the investigator's judgment, cause unacceptable safety risks, contraindicate
patient participation in the clinical study or compromise compliance with the
protocol: (e.g., chronic pancreatitis, chronic active hepatitis, active untreated or
uncontrolled fungal, bacterial or viral infections, etc.)
- Clinically significant, uncontrolled heart disease and/or cardiac repolarization
abnormality, including any of the following:
- History of documented myocardial infarction (MI), angina pectoris, symptomatic
pericarditis, or coronary artery bypass graft (CABG) within 6 months prior to
study entry
- Documented cardiomyopathy
- Left Ventricular Ejection Fraction (LVEF) < 50% as determined by Multiple Gated
acquisition (MUGA) scan or echocardiogram (ECHO)
- Long QT syndrome or family history of idiopathic sudden death or congenital long
QT syndrome, or any of the following:
- Risk factors for Torsades de Pointe (TdP) including uncorrected hypocalcemia,
hypokalemia or hypomagnesemia, history of cardiac failure, or history of
clinically significant/symptomatic bradycardia
- Concomitant medication(s) with a known risk to prolong the QT interval and/or
known to cause Torsades de Pointe that cannot be discontinued or replaced by safe
alternative medication (e.g., within 5 half-lives or 7 days prior to starting
study drug)
- Inability to determine the QTcF interval
- Clinically significant cardiac arrhythmias (e.g., ventricular tachycardia),
complete left bundle branch block, high-grade AV block (e.g., bifascicular block,
Mobitz type II and third degree AV block)
- Systolic Blood Pressure (SBP) >160 or <90 mmHg
14. Patient is currently receiving any of the following substances within 7 days before
randomization:
1. Concomitant medications, herbal supplements, and/or fruits (e.g. grapefruit,
pomelos, starfruit, Seville oranges) and their juices that are known as strong
inhibitors or inducers of CYP3A4/5;
2. Medications that have a narrow therapeutic window and are predominantly
metabolized through CYP3A4/5;
15. Vulnerable persons as defined by article L1121-5 - 8:
1. Pregnant women, women in labor or breast-feeding mothers, persons deprived of
their freedom by judicial or administrative decision, persons hospitalized
without their consent by virtue of articles L. 3212-1 and L. 3213-1 and who are
not subject to the provisions of article L. 1121-8
2. Persons admitted to a social or health facility for reasons other than research;
3. Adults subject to a legal protection order or unable to give their consent.
16. Concurrent enrolment in another clinical trial using an investigational anti-cancer
treatment within 28 days prior to the first dose of study treatment.
Criteria for the Ribociclib and Radiotherapy concomitant phase Inclusion criteria
1. Patient registered in the study-screening phase;
2. Patient receiving, during the registration phase, 3 cycles of Ribociclib at 600mg
without dose decreased;
3. Have a performance status of 0 to 2 on the ECOG Performance Scale;
4. Not immediately operable (stage of disease, comorbidities or refusal of surgery) with
tumor in place;
5. Measurable disease based on RECIST 1.1;
6. Demonstrate adequate organ functions:
1. Hemoglobin > 9 g/dL;
2. Absolute neutrophil count > 1.5 G/L;
3. Platelets > 100 G/L;
4. INR ≤1.5 (unless the patient is receiving anticoagulants and the INR is within
the therapeutic range of intended use for that anticoagulant within 7 days prior
to the first dose of study drug);
5. Total serum bilirubin < ULN; or total bilirubin ≤ 3.0 × ULN or direct bilirubin ≤
1.5 × ULN; in patients with well documented Gilbert's Syndrome;
6. AST and ALT <2.5 x ULN;
7. Alkaline Phosphatase < 2.5 x ULN
8. Calculated creatinine clearance > 30 ml/min using MDRD formula;
9. Patient must have the following laboratory values within normal limits or
corrected to within normal limits with supplements (the local laboratory value
should be documented within normal limits after the correction) before inclusion:
- Potassium
- Magnesium
- Total Calcium (corrected for serum albumin);
7. Standard 12-lead ECG values defined as the mean of the triplicate ECGs
- QTcF interval at screening < 450 msec (QT interval using Fridericia's correction)
- Mean resting heart rate 50-90 bpm (determined from the ECG)Indication of
treatment with hormone therapy and hypofractioned radiotherapy;
8. Patients having taken cognizance of the information sheet and having signed the
informed consent;
9. Patients covered by medical insurance.
10. Must be able to swallow ribociclib;
11. Subjects must be able to communicate with the investigator and comply with the
requirements of the study procedures;
12. Must be willing to remain at the clinical site as required by the protocol.
Exclusion criteria
1. Patient eligible to resection surgery after 3 cycles of Ribociclib;
2. Patient eligible to neoadjuvant chemotherapy;
3. Concomitant bilateral breast cancer;
4. Known additional malignancy. Exceptions include basal cell carcinoma of the skin or in
situ cervical cancer that has undergone potentially curative therapy;
5. Contraindication for hormone therapy, Ribobociblib or radiotherapy;
6. Patient has any other concurrent severe and/or uncontrolled medical condition that
would, in the investigator's judgment, cause unacceptable safety risks, contraindicate
patient participation in the clinical study or compromise compliance with the
protocol: (e.g., chronic pancreatitis, chronic active hepatitis, active untreated or
uncontrolled fungal, bacterial or viral infections, etc.)
- Clinically significant, uncontrolled heart disease and/or cardiac repolarization
abnormality, including any of the following:
- History of documented myocardial infarction (MI), angina pectoris, symptomatic
pericarditis, or coronary artery bypass graft (CABG) within 6 months prior to
study entry
- Documented cardiomyopathy
- Left Ventricular Ejection Fraction (LVEF) < 50% as determined by Multiple Gated
acquisition (MUGA) scan or echocardiogram (ECHO)
- Long QT syndrome or family history of idiopathic sudden death or congenital long
QT syndrome, or any of the following:
- Risk factors for Torsades de Pointe (TdP) including uncorrected hypocalcemia,
hypokalemia or hypomagnesemia, history of cardiac failure, or history of
clinically significant/symptomatic bradycardia
- Concomitant medication(s) with a known risk to prolong the QT interval and/or
known to cause Torsades de Pointe that cannot be discontinued or replaced by safe
alternative medication (e.g., within 5 half-lives or 7 days prior to starting
study drug)
- Inability to determine the QTcF interval
- Clinically significant cardiac arrhythmias (e.g., ventricular tachycardia),
complete left bundle branch block, high-grade AV block (e.g., bifascicular block,
Mobitz type II and third degree AV block)
- Systolic Blood Pressure (SBP) >160 or <90 mmHg
7. Severe dementia;
8. Patients unable to express their consent;
9. Vulnerable persons as defined by article L1121-5 - 8:
1. Pregnant women, women in labor or breast-feeding mothers, persons deprived of
their freedom by judicial or administrative decision, persons hospitalized
without their consent by virtue of articles L. 3212-1 and L. 3213-1 and who are
not subject to the provisions of article L. 1121-8;
2. Persons admitted to a social or health facility for reasons other than research;
3. Adults subject to a legal protection order or unable to give their consent.
10. Concurrent enrolment in another clinical trial using an investigational anti-cancer
treatment.