Study to Assess the Effect of E-OA-07 on Acute Pain Response in Subjects Suffering From Knee OA
Status:
Completed
Trial end date:
2015-02-01
Target enrollment:
Participant gender:
Summary
The repetitive motions associated with active life and many sports can increase the wear and
tear to the joints that leads to decrease in flexibility and joint pain finally heading its
way to osteoarthritis. Activities such as jumping, running can wear away the cartilage that
supports and cushions the joints of hands and knees, causing bones to rub against each other.
Injuries stemming from repetitive motions can also cause and worsen the joint pain.
Joint pain is discomfort that arises from any joint . Irrespective of the underlying
mechanisms, joint pain usually originates in activation of nociceptors, or free nerve
endings. Complex neuronal activation occurs, which involves not only local sensitization of
joint nociceptors but also modifications in central pain pathways.
Even though, the numerous pharmacological interventions are available for joint pain, there
is much debate amongst clinicians about the best approach to the treatment of joint pain.
NSAIDs which is frequently used for treatment in such cases, carries concerns related to
gastro-intestinal system, cardiovascular system as well as central nervous system .
Hence there is a need of a safer alternative treatment option for relieving acute joint pain
which is comparable to the modern medicines, without posing concerns to the subject's general
well being.
Herbs are known to be used since ages in traditional literature and do not pose any potential
health concern. Inspite of such positive attributes herbs are not employed in treatment of
acute pains as there is lack of evidence proving the same.
In order to address the need of the hour Enovate Biolife has invented a novel poly herbal
formulation E-OA-07 (Lanconone). Lanconone has been studied previously in patients with
osteoarthritis has been proven efficacious . It has a good history of marketing and is sold
in the United States, with no reported adverse event related to the product. However there is
no concrete evidence proving the product's acute pain relieving dynamics, hence the current
study has been employed to comprehend the effect of lanconone in joint acute pain.