Overview

Study to Assess Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of Palovarotene Ophthalmic Solution in Healthy Adult Subjects

Status:
Completed
Trial end date:
2019-01-03
Target enrollment:
0
Participant gender:
All
Summary
Dry eye disease (DED) is a keratoconjunctive disorder that "is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. The goal of this study is to assess the safety, tolerability, and pharmacokinetics (PK) of multiple ascending doses of palovarotene ophthalmic solution in healthy adult subjects.
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Clementia Pharmaceuticals Inc.
Collaborator:
Ipsen
Criteria
Key Inclusion Criteria:

- Healthy, adult, male or female, 18 to 55 years of age, inclusive, at screening.

- Continuous non-smoker who had not used nicotine containing products for at least 3
months prior to the first dosing and throughout the study, based on subject
self-reporting.

- Body mass index (BMI) ≥18.0 and ≤32.0 kg/m2 at screening.

- Medically healthy as deemed by the Investigator or delegate and determined by medical
history, physical examination, vital signs, 12-lead ECGs, and clinical laboratory
results obtained within 28 days before the start of the study.

- Tolerate topical administration to the eye.

- Best corrected visual acuity is equal or better than 70 Early Treatment Diabetic
Retinopathy Study (ETDRS) letter score in both eyes.

Key Exclusion Criteria:

- Mentally or legally incapacitated or had significant emotional problems at the time of
the screening visit or expected during the conduct of the study.

- History or presence of clinically significant medical (systemic or ophthalmic) or
psychiatric condition or disease in the opinion of the Investigator or delegate.

- History of any illness that, in the opinion of the Investigator or delegate, might
have confounded the results of the study or posed an additional risk to the subject by
their participation in the study.

- History or presence of alcoholism or drug abuse within the past 18 months prior to the
first dosing.

- History or presence of hypersensitivity or idiosyncratic reaction to the study drug,
systemic retinoids such as isotretinoin or related compounds (e.g., topical
tretinoins, vitamin A), fluorescein, or parabens or to the inactive ingredients in the
study formulation.

- History of any ocular surgery or laser within the past 6 months prior to screening.

- History of herpes simplex keratitis.

- History or presence of:

1. Any chronic eye disease other than refractive error, incipient cataract,
strabismic amblyopia, or anisometropic amblyopia.

2. Acute eye disease (such as infection, corneal abrasion, or allergy) within the
past 6 months from screening.

- Any currently active ocular condition that required use of topical eye drops.

- Had an intraocular pressure >21 mmHg.

- If ophthalmological examination at screening or Day 1 predose revealed abnormalities
of the cornea, evidence of ocular infection, inflammation (dry eyes, blepharitis,
allergic conjunctivitis, iritis, and uveitis), advanced or moderately injected
pterygium, keratitis, narrow anterior chamber angles, clinically significant Meibomian
gland dysfunction, or any finding in either the anterior segment or posterior segment
of the eye, that could have compromised the study as per Investigator or delegate
discretion.

- Any macular integrity issues or optic nerve head (ONH) cupping/abnormality on retinal
exam.

- Occurrence of active seasonal allergies including ocular allergies (e.g., annual hay
fever).

- Needed to wear contact lenses during the study.

- Positive results at screening for human immunodeficiency virus, hepatitis B surface
antigen, or hepatitis C virus.

- Unable to refrain from or anticipates the use of any drug, including prescription and
non-prescription medications, herbal remedies, or vitamin supplements beginning 14
days prior to the first dosing and throughout the study, unless permitted by the
Investigator or delegate.

- Any drugs known to be significant inhibitors and inducers of CYP3A4 enzymes, including
St. John's Wort, for 30 days prior to the first dosing and throughout the study.

- Ocular medication of any kind (including artificial tears), antihistamines,
anticholinergics, and/or oral/nasal steroids for 30 days prior to the first dosing and
throughout the study.

- Isotretinoin or other systemic retinoids beginning 30 days or 5 half-lives, whichever
was longer