Study to Assess Efficacy, Safety and Mechanism of Rupatadine in Cold Urticaria
Status:
Completed
Trial end date:
2014-10-01
Target enrollment:
Participant gender:
Summary
Main objective of this study is to evaluate the efficacy of rupatadine in 20 mg and 40 mg
doses in the development of symptoms of cold contact urticaria. For this purpose, a Peltier
element-based electronic provocation device (TempTest®, emo systems GmbH, Berlin, Germany)
will be used. This allows skin exposure to 12 different temperatures from 4 to 42 °C
simultaneously in a standardized and reproducible way and thus the determination of
individual temperature and/or stimulation time thresholds.
In addition mediators related from activated must cells such as histamine, PAF, PGD2 should
be identified in the period between the application of stimulus and the appearance of
symptoms of cold urticaria and should be characterized qualitatively and quantitatively.