Study to Assess Dopamine Receptor Modulation With Rotigotine to Enhance Morphine Analgesia in the Dental Model
Status:
Unknown status
Trial end date:
2017-01-01
Target enrollment:
Participant gender:
Summary
Narcotics are widely used as the mainstay of pain treatment, although increasing doses are
required over time as the individual becomes tolerant to their effects. This can lead to the
development of dependence and abuse of these drugs. Research has identified a new way to
decrease the risk of developing tolerance to narcotics, by giving at the same time a drug
called rotigotine ("Neupro"). Rotigotine interferes with the body's chemical dopamine and is
FDA-approved for the management of Parkinson's Disease.
The purpose of this research study is to look at side effects and pain control in healthy
people after removal of wisdom teeth, which usually causes pain. It is thought that by giving
the study drug rotigotine with the narcotic pain reliever, there will be pain control that
will extend longer than when giving the narcotic alone.