Overview
Study to Assess Bemiparin Pharmacokinetics in Renal Insufficiency and in the Elderly
Status:
Completed
Completed
Trial end date:
2011-03-01
2011-03-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
Open pharmacokinetic study with 5 parallel groups and two treatment phases (bemiparin 3,500 IU multiple dose and bemiparin 115 IU/kg single dose). The bemiparin pharmacokinetic profile will be assessed by measuring its effects on the coagulation cascade. Plasma anti-Xa activity (measured using chromogenic amidolytic assay) in IU per milliliter will be the primary endpoint to assess the pharmacokinetic profile of bemiparin.Phase:
Phase 1Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Rovi Pharmaceuticals LaboratoriesTreatments:
Bemiparin
Heparin, Low-Molecular-Weight
Criteria
Inclusion Criteria:Non-elderly healthy volunteers (Group I):
- Male or female subjects aged between 18 and 65 years
- body weight, clinical history, physical examination, vital signs (systolic and
diastolic blood pressure, heart beat rate and body temperature), ECG and laboratory
tests (hemogram and biochemistry) within normal range
- without evidence of significant organic or psychiatric illness
- who have accepted to participate in the study and have signed the written informed
consent.
Patients with renal insufficiency (Groups II, III and IV):
- Male or female subjects aged between 18 and 65 years, who will be assigned to one of
the following groups according to renal function:
- Group II: mild renal insufficiency (creatinine clearance > 50 to 80 ml/min);
- Group III: Moderate renal insufficiency (creatinine clearance: 30 to 50 ml/min);
- Group IV: Severe renal insufficiency (creatinine clearance < 30 ml/min). The
degree of renal insufficiency will be calculated on the basis of determination of
creatinine clearance measuring total urinary output over a 24-h period and serum
creatinine levels. Urine samples will be collected no more than 2 weeks before
the first experimental period.
- Patients with renal insufficiency must have a stable renal function during the 3
months before their inclusion in the study.
- They must have a body weight between 45 and 110 Kg.
- They have to accept to participate in the study and have signed the written informed
consent.
Elderly healthy volunteers (Group V):
- Male or female subjects aged > 65 years old who fulfill with the remaining inclusion
criteria specified for non-elderly healthy volunteers.
Exclusion Criteria:
Non-elderly healthy volunteers (Group I):
- Previous history of alcoholism or drugs consumption
- Important consumer of exciting drinks
- Hypersensitivity, allergy, idiosyncrasy to medicines
- Taking another medication four weeks before the initiation of the trial including
medication without prescription and medicinal plants
- Positive serology of hepatitis B, C or HIV virus
- History or clinic evidence of concomitant disease
- Familiar history of coagulation's disorders
- surgery within the previous 6 months
- Women who are pregnant or who are not using effective contra conceptive methods
- Ethanol, cannabis, cocaine, amphetamine, benzodiazepin or opiate in urine
- Current platelet count < 100.000/mm3 or serum K > 5,5 mEq/L
- Any contraindication to bemiparin administration in order to authorized summary
product characteristics
- Healthy volunteers who are not participating in another clinical trial or have not
done so in the past 2 months
- To give blood in the four weeks before beginning of the trial
Patients with renal insufficiency or elderly healthy volunteers (Groups II, III, IV, V):
- Previous history of alcoholism or drugs consumption
- Important consumer of exciting drinks
- Hypersensitivity, allergy, idiosyncrasy to medicines
- Treatment with enzymatic inhibitors or inductors medicines
- Administration with ASA of dosis > 125 mg/day and/or NDAIs with half-life > 20 hours
or with high antiagregant effect during the previous ten days to the inclusion
- Chronic hepatopatology
- bilirubin levels > 1,5 mg/dl and/or increment of AST/ALT levels twice higher than
maximum limit of normality
- prothrombin time 20% higher than maximun limit of normality and haemoglobine < 8gr/dl
or albumim levels <3gr/dl
- Previous history of acute infarction of myocardium, cardiac ischemic or arrhythmia
- Acute illness in the previous week to the participation
- Familiar history of coagulation's disorders
- surgery within the previous 6 months
- Women who are pregnant or who are not using effective contra conceptive methods
- Ethanol, cannabis, cocaine, amphetamine, benzodiazepin or opiate in urine
- Current platelet count < 75.000/mm3 or serum K > 6 mEq/L
- Any contraindication to bemiparin administration in order to authorized summary
product characteristics
- Healthy volunteers who are not participating in another clinical trial or have not
done so in the past 2 months
- To give blood in the four weeks before beginning of the trial
- Subjects in haemodialysis or peritoneal dialysis