Study on the Relationship Between Asymmetric Vascular Sign of Cortex and Prognosis in Massive Cerebral Infarction
Status:
Recruiting
Trial end date:
2021-09-09
Target enrollment:
Participant gender:
Summary
Susceptibility weighted imaging (SWI) technology has developed in the decade which is being a
kind of cerebrovascular disease diagnostic tools in the clinical application, especially for
paramagnetic material (such as DNA hemoglobin and hemosiderin) has a high sensitivity.
The change of the signal on SWI bases on the change of local oxygenated hemoglobin content in
the blood and deaeration hemoglobin content ratio, which can be used to indirectly reflect
the hypoxia group oxygen intake fraction (OEF) and cerebral metabolic rate. When the
intracranial vascular occlusion, corresponding responsibility vascular blood flow area of
brain tissue will occur hypoperfusion, brain tissue will improve the compensation in
accordance with its own OEF, causing ischemia area inside the venous drainage of deaeration
hemoglobin content ratio increases and the hypointensity on SWI ,which display the asymmetric
cortical vessel sign (ACVS). Studies have suggested that ACVS is more prone to early
neurological deterioration and has a poor long-term outcome. After recanalization of ischemic
stroke, the presence of equal CVS(return to normal) on SWI is associated with a good clinical
outcome. In addition, the relationship between ACVS grade and collateral circulation in
patients with acute ischemic stroke has been studied. For patients with massive cerebral
infarction, the relationship between ACVS on SWI and the clinical prognosis of cerebral edema
and cerebral hemodynamics is not completely clear. In this study, the clinical data of
patients with massive cerebral infarction will be analyzed to explore the relationship
between ACVS, cerebral edema , cerebral hemodynamic and clinical prognosis.
Sodium aescinate is widely used in cerebral edema caused by cerebral hemorrhage or cerebral
infarction.The main mechanism of sodium aescinate is anti - inflammatory, anti - exudate,
anti - oxygen free radical, anti - edema, increase vein tension, improve blood circulation
and nerve protection. In this study, investigators will investigate whether the application
of sodium aescinate had an effect on ACVS on SWI in patients with massive cerebral
infarction. Plasma s100-β, procalcitonin, neutrophil count, serum fibronectin, and
endothelin-1 could predict cerebral edema in patients with cerebral infarction, this study
will analyze the relationship between these markers and ACVS on SWI in patients with massive
cerebral infarction.