Study on the Optimal Strategy of Chinese Patients With Bulimia Nervosa After Fluoxetine Treatment
Status:
Recruiting
Trial end date:
2022-11-30
Target enrollment:
Participant gender:
Summary
Current treatment strategies for BN are limited. The total effective rate of pharmacotherapy
and psychotherapy is only about 50%.The preliminary studies and clinical experience of this
project indicate that :(1) fluoxetine, DBT and CBT were effective in controlling binge eating
and purging behaviors in patients with BN;(2) the short-term efficacy of fluoxetine group is
better than DBT group ;(3) treatment with fluoxetine is more convenient and easier to be
accepted by Chinese patient and Chinese doctors. BN patients who had poor response to
fluoxetine with adequate dosage and duration would receive a secondary treatment, and
randomly assigned to three groups: topiramate, fluoxetine +CBT, fluoxetine +DBT.This study
was designed as a multicenter randomized controlled study, in which 550 patients with bulimia
were enrolled. During 1year of follow-up, the onset time, short-term and long-term efficacy,
duration of treatment and the cost of each treatment strategies would be observed and
compared.
Phase:
N/A
Details
Lead Sponsor:
Shanghai Mental Health Center
Collaborators:
Huadong Hospital Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai Tongji Hospital, Tongji University School of Medicine