Study on the Mechanism of Colla Corri Asini in the Treatment of Thalassemia Patients With Pregnancy Anemia
Status:
Unknown status
Trial end date:
2019-02-28
Target enrollment:
Participant gender:
Summary
This study aims to explore the pathways and targets of regulating globin expression, which
might be related to Colla corii asini (CCA, E'jiao) treating anemia in pregnant women with
β-thalassemia. Firstly, ten pregnant patients who meet inclusion criteria will be randomly
assigned to either the treatment group or control group in a 1: 1 ratio. The patients in the
treatment group will be given 15 g of CCA daily for 4 weeks and followed up, while the
control group will be treated with nothing and followed up in the same period. The
transcriptional test and bioinformatics analysis would be conducted to detect and determine
the potential pathways and targets of regulating globin expression before and after the
treatment. Secondly, sixty pregnant patients who meet inclusion criteria will be randomly
assigned to either the treatment group or control group in a 2: 1 ratio. The treatment group
and control group respectively received the same treatment and follow-up regimen as the
transcriptional study mentioned above. According to the results of the transcriptional study,
the target gene signaling pathway molecules, Hb concentration, and the levels of α-、β-、γ- and
δ-globin will be detected and compared.
Phase:
Phase 4
Details
Lead Sponsor:
The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine