Study of the Efficacy of Losartan on Aortic Dilatation in Patients With Marfan Syndrome

• Status: Terminated
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate if losartan limits aortic dilatation in patients with Marfan syndrome.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Angiotensin II Type 1 Receptor Blockers; Losartan

Criteria

Inclusion Criteria:

• 10 years or older

• Marfan syndrome according to international criteria Signed informed consent

Exclusion Criteria:

• Previous surgery of the ascending aorta, or surgery planned

• Non echogenicity

• Contre-indication lactose

• Pregnancy on going or planned within 3 years

• Breast feeding

• Participation in another clinical study

• Non member of the social security or CMU