Study of the Effects of MDMA/Ecstasy on Water Regulation, Sleep, and Cognition.
Status:
Completed
Trial end date:
2011-02-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to measure the effects of MDMA on sleep, mood, thinking, and how
your body retains water. The researchers are interested in the effects that occur a few hours
after taking MDMA as well as effects occurring over the next two days. We will study these
effects in a standardized, controlled setting at the Clinical and Translational Science
Institute (CTSI) Clinical Research Center (CRC) located at San Francisco General Hospital.
The primary hypotheses are:
1. MDMA will induce sleep disruption, as indicated by comprehensive polysomnography, wrist
actigraphy, and self-report sleep measures
2. MDMA will alter sodium and water homeostasis by either increasing or blunting the
suppression of arginine vasopressin levels and decreasing free water excretion. Effects
will be exacerbated by water loading.
Secondary hypotheses:
1. Acutely, MDMA will increase both positive and negative arousal, and to increase
sociability but not autonomy.
2. Acutely, MDMA will increase risk-taking and willingness to donate money to others in an
economic decision making task.
3. MDMA will decrease the stressful effects of talking about a negatively-valenced
autobiographical but will increase recall for details for these episodes.
4. MDMA will increase oxidative stress markers and possible ameliorating factors (e.g.,
ADMA).
5. The short form of the serotonin transported promoter region will be associated with
greater acute and discontinuation effects of MDMA.
Phase:
N/A
Details
Lead Sponsor:
California Pacific Medical Center Research Institute