Study of the Effects of Intensive Treatment of Periodontitis on Blood Pressure Control

• Status: Unknown status
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Hypertensive patients with chronic periodontitis will be randomized to either intensive treatment or supragingival hygienic treatment and the effects on blood pressure will be identified.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jagiellonian University
• Treatments: Chlorhexidine; Chlorhexidine gluconate

Criteria

Inclusion Criteria:

• Periodontitis with three or more periodontal pockets with a probing depth (PD) > 5mm

• Bleeding of these periodontal pockets on probing

• Have at least 20 natural teeth

• Provide informed consent and willingness to cooperate with the study protocol

• Age >25 years old

• Absence of other significant oral infections.

• Primary Hypertension on stable treatment

Exclusion Criteria:

• Clinical symptoms of acute inflammatory disorders incl flu, rhinitis, sinusitis etc. within past 3 weeks

• Hospitalization for any reason within the past 3 months; Life expectancy of < 3 years;

• Allergic disorders; History of chronic infectious disease, Chronic Obstructive Pulmonary Disease (COPD), tuberculosis; chronic hepatitis B or C infection; interstitial pneumonitis, bronchiectasis; known chronic pericardial effusion, pleural effusion, or ascites; liver disease;

• Other known chronic inflammatory or autoimmune condition such as lupus or rheumatoid arthritis, ulcerative colitis or Crohn's disease

• Secondary hypertension (known plasma renin screening, abdominal ultrasound with doppler and other investigations)

• Non-basal cell malignancy or treated myelo or lymphoproliferative disease within the past 5 years;

• Known HIV positive; Immunizations within past 3 months

• Individual requires chronic oxygen support or mechanical ventilation other than nocturnal respiratory support for sleep apnea.

• Primary pulmonary hypertension.

• Use of systemic or local steroids or immunosuppressive agents within 6 months of the inclusion.

• Individual is pregnant or nursing

• History of alcohol abuse or unwillingness to limit alcohol consumption to less than 4 drinks per week