Study of the Effects of Anakinra in Corticosteroid-resistant Subjects With Sudden Sensorineural Hearing Loss
Status:
Terminated
Trial end date:
2015-07-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine if anakinra (an interleukin-1 receptor antagonist)
can improve hearing thresholds in patients with sudden sensorineural hearing loss that did
not respond to oral steroid therapy. The patients to be enrolled will have recently completed
a course of oral steroids and demonstrated no change in their audiometric thresholds
following corticosteroid therapy.
The investigators will be measuring hearing thresholds (Pure tone average and word
recognition scores) before and after anakinra and correlating these findings with circulating
IL-1 levels in the patient's blood.