Study of the Effect of Tranexamic Acid Administered to Patients With Hip Fractures. Can Blood Loss be Reduced?
Status:
Terminated
Trial end date:
2014-08-01
Target enrollment:
Participant gender:
Summary
The effect of Tranexamic acid on blood loss, hemoglobin and transfusions in patients with
pertrochanteric hip fractures.
Tranexamic acid is a well known drug used in many types of surgery. The investigators wish to
investigate if the use of tranexamic acid can reduce the peri- and post-operative blood loss
in patients who undergo surgery with a short intramedullary nail, for a pertrochanteric hip
fracture.
An interim analysis was planned when reaching 60 inclusions. The interim analysis was
conducted only on the primary outcome (TBL). A difference in TBL of no less than 500 ml was
considered a reason to halt the study. The 0.001 level was chosen as a simple approach to
this interim analysis from the Haybittle-Peto boundary