Study of the Effect of N-acetyl Cysteine on the Renal Graft Function Biomarkers (IL18, NGAL)

• Status: Unknown status
• Trial end date: 2012-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate the effect of (NAC) N-Acetyl Cysteine on biomarkers of Delayed Graft Function (DGF), including Neutrophil Gelatinase Associated Lipocalin (NGAL) and Intereleukin 18 (IL18).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shahid Beheshti University of Medical Sciences
• Treatments: Acetylcysteine; N-monoacetylcystine

Criteria

Inclusion Criteria:

• patient receiving transplantation from living donors

Exclusion Criteria:

• having a neoplastic disease

• brain tumor

• having inflammatory diseases in their active phase (SLE)

• an acute infection, meningitis, sepsis

• Sickle Cell Disease

• Pregnancy

• Cardio-renal syndrome

• endogenous Cushing's syndrome

• chronic use of cimetidine

• a history of acute pancreatitis in recent months

• Multiple Sclerosis

• cardiac bypass in a recent month

• cirrhosis due to Hepatitis C

• having Alzheimer's disease

• having a untreated major depressive illness or schizophrenia

• Stroke in recent months

• Hyperoxaluria

• sensitivity to sulfonamides