Study of the Effect of Intramuscular Ephedrine on the Incidence of Nausea and Vomiting During Elective Cesarean Section

• Status: Completed
• Trial end date: 2010-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this research study is to investigate if the incidence of nausea and vomiting that subjects experience during and after a Cesarean section can be reduced by giving a shot of the drug ephedrine into the thigh muscle at the time of spinal anesthesia administration.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Weill Medical College of Cornell University
• Collaborator: New York Presbyterian Hospital
• Treatments: Ephedrine; Pseudoephedrine

Criteria

Inclusion Criteria:

• Must be pregnant with a single baby

• Must be at term in their pregnancy (estimated gestational age of at least 38 weeks)

• Must be scheduled for an elective Cesarean section

• Must be between 60-70" tall

• Must be free of severe systemic disease (ASA class I or II)

Exclusion Criteria:

• Contraindication to spinal anesthesia

• Any allergy to any of the medications included in the study

• History of pregnancy-induced hypertension or preeclampsia

• History of preexisting hypertension

• Diabetes mellitus

• Hyperemesis gravidum

• Previous perioperative nausea and vomiting

• History of motion sickness

• Women carrying a fetus with a known abnormality will also be excluded from the study