Study of the Effect of Dipyrone, Ibuprofen, Paracetamol and Parecoxib on the Platelet Aggregation in Analgetic Dosages
Status:
Completed
Trial end date:
2004-12-01
Target enrollment:
Participant gender:
Summary
Dipyrone is suggested to inhibit the platelet aggregation comparable to th effect of
traditional analgetic substances like Ibuprofen. To verify this hypothesis the investigators
conducted the study in comparing patients undergoing traumatologic, visceral or plastic
surgical procedures. The investigators randomized them to four groups receiving common
analgetic doses of either dipyrone, acetaminophen (paracetamol) or valdecoxib/parecoxib. The
investigators took blood samples before initiation of the study drug, 1h, 4hs and 24hs after
first intake. The investigators compared the aggregation via aggregometry of platelet rich
plasma.