Study of Whole-brain Irradiation With Chloroquine for Brain Metastases
Status:
Terminated
Trial end date:
2013-01-01
Target enrollment:
Participant gender:
Summary
Background and purposes:Chloroquine (CLQ), an antimalarial drug, has a lysosomatrophic effect
associate with increase the sensibility of Radiation through leakage of hidroliticenzimes,
increase of apoptosis, autophagy mediated by lysosomalhidrolases and increase of oxidative
stress "in vitro". In this phase II study we evaluated the efficacy and safety as
radiosensitizing of the Chloroquine plus concomitant 30 Gray (Gy) of Whole-brain irradiation
(WBI)in patients with brain metastases (BM) from solid tumors.