Overview

Study of Vorinostat (MK0683), an Histone Deacetylase (HDAC) Inhibitor in Combination With Bortezomib in Patients With Relapsed or Refractory Multiple Myeloma (MK-0683-095)

Status:
Completed
Trial end date:
2012-04-09
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to evaluate the clinical activity of vorinostat in combination with bortezomib in participants with relapsed or refractory multiple myeloma after at least 2 prior treatment regimens. The primary objective is to define the objective response rate (RR) associated with the administration of vorinostat in combination with bortezomib to patients with relapsed and refractory multiple myeloma after at least 2 prior treatment regimens. The primary hypothesis of the study is the administration of vorinostat in combination with bortezomib will result in a clinically meaningful rate of objective response.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Merck Sharp & Dohme Corp.
Treatments:
BB 1101
Bortezomib
Dexamethasone
Dexamethasone 21-phosphate
Dexamethasone acetate
Histone Deacetylase Inhibitors
Vorinostat
Criteria
Inclusion Criteria:

- Has an established diagnosis of multiple myeloma based on myeloma diagnostic criteria

- Must have adequate organ function

- Is refractory to prior bortezomib regimen and have also been exposed to prior
Immunomodulatory imide drugs (IMiD: thalidimide or lenalidmide)

- Has relapsed and refractory multiple myeloma after at least 2 prior treatment regimens

- Has performance status of ≤ 2 on the Eastern Cooperative Oncology Group (ECOG)
Performance Scale

- Has measurable disease, defined as any quantifiable serum monoclonal (M) protein value
and, where applicable, urine light chain of ≥200 mg/24 hours

- Female participants are not pregnant and not breastfeeding, and are not a woman of
childbearing potential (WOCBP) or are a WOCBP who agrees to follow contraceptive
guidance during the treatment period and for at least 30 days after the last dose of
study intervention

- Male participants must agree to use approved contraception during the treatment period
and for at least 30 days after the last dose of study intervention and refrain from
donating sperm during this period

- Is relapsed, refractory, intolerant, and/or ineligible (in the opinion of the
investigator) to other therapies including an IMiD (thalidomide or lenalidomide)

- Is refractory to bortezomib (no response on prior bortezomib containing regimen or
progression on or within 60 days of bortezomib containing regimen

Exclusion Criteria:

- Has known hypersensitivity to any components of bortezomib or vorinostat

- Has had a prior allogeneic bone marrow transplant or plans to undergo any type of bone
marrow transplantation within 4 weeks of the initiation of study therapy

- Has an active systemic infection

- Has acute diffuse infiltrative pulmonary disease or pericardial disease

- Has known hypersensitivity to any components of bortezomib or vorinostat

- Has active Hepatitis B or C, plasma cell leukemia, or is human immunodeficiency virus
(HIV) positive

- Has history of a prior malignancy with the exception of cervical intraepithelial
neoplasia; non-melanoma skin cancer; adequately treated localized prostate carcinoma
with prostate specific antigen (PSA) < 0.1; or who has undergone potentially curative
therapy with no evidence of that disease for five years, or who is deemed at low risk
for recurrence by his/her treating physician

- Has known central nervous system (CNS) metastases and/or carcinomatous meningitis

- Has plasma cell leukemia defined as the presence of more than 20% plasma cells in the
peripheral blood and an absolute plasma cell count of at least 2000/μL

- Has a history of a gastrointestinal surgery or other procedures that might, in the
opinion of the Investigator, interfere with the absorption or swallowing of the study
drug

- Has preexisting National Cancer Institute (NCI) Common Toxicity Criteria (CTC) Grade 1
neuropathy with pain or >Grade 2 neuropathy