Study of Vitamin D and Effect on Heart Disease and Insulin Resistance

• Status: Completed
• Trial end date: 2010-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate how Vitamin D affects endothelial function, inflammation, lipids, insulin resistance, vitamin D levels, and parathyroid hormone (PTH).

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospitals Cleveland Medical Center
• Treatments: Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• HIV infected

• HIV-RNA < 400 copies/ml at study entry and for 12 wks. prior

• 25-hydroxyvitamin D level <20

• On a stable anti-retroviral (ARV) regimen for at least 12 weeks prior to study entry

Exclusion Criteria:

• Pregnancy or Breast Feeding

• Diabetes

• Creatinine Clearance <50

• Any active infectious or inflammatory condition

• aspartate aminotransferase (AST) or alanine aminotransferase (ALT) >2.5 within 6 months prior to study entry