Study of Vitamin D Supplementation on Improvement of Gums Health

• Status: Completed
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

There is a gap in knowledge regarding the effects of Vitamin D supplementation on periodontal status in pregnant wome. The investigators aim to evaluate the potential benefit, if any of vitamin D supplementation during pregnancy on periodontal disease and relevant outcomes including burden of infections and prematurity rates.

the investigators hypothesize that

1. Vitamin D supplementation during pregnancy improves the periodontal health.

2. There is an association between inflammatory biomarkers and periodontal health of pregnant females.

3. Vitamin D supplementation improves the outcomes of pregnancy such as prematurity rates and birth weight

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Aga Khan University
• Treatments: Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Pregnant females from 12-20 weeks of gestation who agree to participate in the study.

• Presence of at least 20 natural teeth in mouth excluding third molars.

• For controls: Non pregnant, healthy females matched with pregnant with respect to age and education.

Exclusion Criteria:

• Pregnant females with high Vitamin D levels,

• Women with metabolic diseases such as diabetes (type 1 or 2).

• Presence of acute dental or periodontal disease

• Presence of systemic disease and/or medication affecting the periodontium;

• Receipt of systemic antibiotic treatment or dental prophylaxis in the previous 3 months and those who do not provide informed consent