Study of Tumor Metabolism by Isotopic Tagging in Patients With High-grade Glioma (CARBONOMIC)

• Status: Terminated
• Trial end date: 2018-01-30
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to follow tumoral proteins metabolism by in vivo no radioactive isotopic tagging (carbon 13 and nitrogen 15).

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Grenoble
• Collaborator: National Cancer Institute, France

Criteria

Inclusion Criteria:

• more or equal than 18 years old

• patient affiliated to social security or similarly regime

• informed consent form signed

• High-grade Glioma tumor suspicion

• Resective surgery indication

• Hematological assessment :

• neutrophils > 1500/mm3

• Platelet > 150 000

• blood Creatinin normal

• alkaline Phosphatases and transaminases no more than two times normal

• Bilirubin < 1.5 times normal

Exclusion Criteria:

• Pregnant women and lactating mothers

• Ward of court or under guardianship

• Adult unable to express their consent

• Person deprived of freedom by judicial or administrative decision

• Person hospitalized without their consent

• Person under legal protection

• Precedent complete macroscopic tumor resective surgery

• No valid inclusion criteria

• Intratumoral hemorrhage MRI detected

• Treatment anticoagulant or antisludge treatments

• Active Infections and non controled or medical affection or psychiatric intercurrent non treated

• Evolutive cerebral oedema without corticoid response

• Non controled Epilepsy without antiepileptics response

• Karnofsky score < 40%

• Weight > 100 kg

• No possibility of resective surgery