Overview

Study of TVB-2640 in Subjects With Nonalcoholic Steatohepatitis (NASH)

Status:
Recruiting
Trial end date:
2023-05-01
Target enrollment:
0
Participant gender:
All
Summary
This is a Phase 2, multi-center, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy on TVB-2640 in subjects with non-alcoholic steatohepatitis (NASH). Subjects will be randomly assigned toTVB-2640 or matching placebo PO QD for 52 weeks, with the first dose administered on Day 1.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Sagimet Biosciences Inc.
Criteria
Inclusion Criteria:

- Must be willing and able to participate in the study and provide written informed
consent.

- Male and female adults ≥18 years of age on the date that written informed consent to
take part in the study is provided.

- Body mass index (BMI) ≥23 kg/m2 and <40 kg/m2 for Asians and ≥25 kg/m2 and <40 kg/m2
for other races.

- Female subjects must be either:

- Not of childbearing potential OR

- Women of childbearing potential (WOCBP) must have a negative serum pregnancy
(beta-human chorionic gonadotropin [β-HCG]) test during Screening, a negative
urine pregnancy test within 24 hours before the first dose of study drug on Day
1, and must agree to perform urine home pregnancy tests monthly between study
visits. WOCBP must not be breastfeeding, not plan to become pregnant during the
study, and must use birth control.

- Must have confirmation of ≥8% liver fat content by MRI-PDFF during the Screening
period.

- Histologic confirmation of NASH: must have had prior liver biopsy within 180 days
before randomization (randomization is within 24 hours of Baseline [Day1]) with
fibrosis stage F2-F3 and a NAS of ≥4

Exclusion Criteria:

- History of harmful alcohol intake for a period of more than 3 consecutive months
within 1 year prior to Screening in the judgement of the Investigator.

- Active substance abuse.

- Gain or loss of >5% of body weight in the 6 months prior to Baseline (Day 1) or >10%
of body weight in the 12 months prior to Screening.

- Type 1 diabetes mellitus by history.

- Positive severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) polymerase chain
reaction (PCR) test within 30 days before Baseline, history of hospitalization for
coronavirus disease-2019 (COVID-19), or history of use of oxygen due to COVID-19. Note
that previous COVID-19 infection alone is not exclusionary and vaccination against
SARS-CoV-2 is allowed, but must be documented.

- Uncontrolled T2DM, defined as HbA1c ≥9% at Screening (subjects with HbA1c ≥9% may be
rescreened on 1 occasion only at the Investigator's discretion).

- Presence of cirrhosis on liver histology (stage 4 fibrosis), according to the
judgement of the central reader, and/or cross sectional.

- Use of glucagon-like peptide-1 (GLP-1) agonists, unless on a stable daily dose for at
least 6 months prior to the Screening visit date, or on a complex oral anti-diabetic
(OAD) regimen (3 or more OADs), unless on a stable dose for at least 6 months prior to
the Screening visit date.

- Subjects with active or quiescent chronic liver disease of etiologies other than NASH
(eg, viral or autoimmune hepatitis, primary sclerosing cholangitis, primary biliary
cholangitis, and 'autoimmune hepatitis-overlap' syndromes, hemochromatosis, Wilson's
disease, alpha 1 antitrypsin deficiency, alcohol-related liver disease, drug-induced
liver disease, and/or infiltrative conditions [eg, sarcoidosis]).

- Current or historic clinically evident hepatic decompensation event (eg, ascites
formation, variceal hemorrhage, hepatic encephalopathy).

- Any subject who has sustained a clinically evident cardiovascular, cerebrovascular,
and/or peripheral vascular event during the 12 months prior to anticipated Baseline
(Day 1) visit date is not eligible for study participation.