Study of Sodium Bicarbonate in Kidney Transplant Recipients

• Status: Completed
• Trial end date: 2012-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the effect of sodium bicarbonate versus no sodium bicarbonate treatment on urinary ammonia levels and urinary transforming growth factor-beta1 (TGF-beta1) excretion in renal transplant patients with low-to-normal serum bicarbonate levels (20 - 28 mmol/L).

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Utah

Criteria

Inclusion Criteria:

• Renal transplant recipients

• Age 21-75 years

• Six months since the time of the most recent transplant

• Serum bicarbonate 20-28mM on the two most recent serum measures with the last six months

• Stable creatinine

Exclusion Criteria:

• Systolic blood pressure > 140mmHg

• Diastolic blood pressure > 90mmHg

• Known ejection fraction <50%

• Clinical diagnosis of heart failure

• Use of >3 antihypertensive agents

• > 1+ edema

• Use of alkali in the preceding 3 months

• History of noncompliance with clinic visits