Study of Sildenafil Citrate on Insulin Resistance in African American
Status:
Completed
Trial end date:
2013-08-01
Target enrollment:
Participant gender:
Summary
Obesity has a greater detrimental impact on the health of African American women than on any
other racial or gender group. Nearly 80% of African American women are overweight or obese in
the United States. Hypertension and insulin resistance are more prevalent among African
American women as compared to men and Caucasians. These conditions put them at increased risk
for the development of diabetes mellitus and cardiovascular disease.
Recent studies have reported that a substance named Nitric Oxide (NO)may have some beneficial
effect on how the body handles blood sugar and blood pressure. Of interest,some studies have
shown that African Americans have decreased function of NO in their blood vessels.
In this study proposal the investigators will test if increasing NO function with a PDE-5
inhibitor (sildenafil citrate) will improve pre-diabetes and the health of the inner layer of
the blood vessels in obese African American women.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Vanderbilt University Vanderbilt University Medical Center
Collaborators:
National Heart, Lung, and Blood Institute (NHLBI) Pfizer