Study of Post-meal Blood Sugar Peaks in Association With Vascular Disease in Childhood Obesity
Status:
Terminated
Trial end date:
2008-09-01
Target enrollment:
Participant gender:
Summary
The main purpose of this study is to determine whether treatment with acarbose attenuates
post-prandial glycemic excursions in non-diabetic/pre-diabetic obese children as determined
by continuous glucose monitoring systems (CGMS). To this effect the current pilot study
involves a 6 week intervention with acarbose given to all subjects with either impaired
glucose tolerance or an area under the curve of >130 mg/dl during the screening oral glucose
tolerance test. Three consecutive days of CGMS are then compared to before and during the
intervention. The secondary objective addressed in this protocol is the collection of
baseline measures of endothelial function in obese and lean children. Even though the
duration of acarbose treatment may be too short to demonstrate a vascular effect, the pre and
post intervention data would serve as preliminary data for anticipated future studies that
assess the vascular effect of reduced post-prandial blood glucose levels.
Phase:
Phase 4
Details
Lead Sponsor:
Yale University
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)